Isothiazolinone Preservatives: Why They’re Now Restricted in Leave‑On Cosmetics
Isothiazolinones (like methylisothiazolinone/MI and methylchloroisothiazolinone/MCI) are potent broad-spectrum preservatives that replaced parabens in many cosmetics. While highly effective at preventing microbial growth, they’ve earned strict regulations due to widespread contact allergies and skin sensitization. Here’s why brands still use them – and the limits you need to know.